When it comes to publishing photos for the web, i always have a sharpen pass done for each one i upload, as well as reducing the image size of course. my process for this is simple. first of all i avoid over sharpening: it tends to transform the image in a pile of unnecessary visual noise. easy to spot when it's the case. it needs to remain subtle. Secondly, my initial process is to create a duplicate layer and paste the photo on it. then apply a sharpen pass (most of the time i use "smart sharpen"). and finally erase the effect on that second layer in areas where the sharpen isn't needed. especially on blurry areas. sharpening Out of focus areas of a photo is never needed.