The Fugitive - Filming Location
The location of the bus leaving the jail is actually a school in Chicago. However, I am adding the screenshot to compare the bus to the location in North Carolina of the bus/train crash scene.
The scene was supposed to take place "20 miles from Menard" where the prisoners were being transported to the correctional facility there. The characters reference area locations, such as the nearby town of Chester, as well as I-55, I-57, I-24, and State Route 13, where US Marshall Sam Gerard recommends checkpoints. However, the train crash actually took place in Dillsboro, North Carolina and is still there, deteriorating.