My newest layout comes from Toy Story 2 - Andy has moved in to a new house which remarkably has an almost identical looking room as his last.
This took me roughly five weeks to create, start to finish. The full layout is 30"x30", and roughly 20" high. The 'scale' I did this in would put the room at roughly 16 feet square.
A few changes have been made to the actual room in the movie. Since this is meant to be seen at shows, one wall needed to be taken out. The missing wall contains the main door to Andy's room - the door on the side is just a closet. Because of this, the dresser and shelves had to be relocated. Fortunately there was plenty of open space - those corners were mostly empty in the movie.
For those of you in the Chicago area who would like to see this in person, this will be going on display for the first time at the Northern Illinois Lego Train Club's Christmas Show in Wheaton, Illinois, Dec. 11th and 12th. I will also be bringing this to Brickworld 2011 as well as numerous smaller local shows all year round.
UPDATE, FEB 2011: I've finally made a video fly-by of this creation. You can see it here: www.youtube.com/watch?v=N3TlF2mhB-4