Focal Adhesions in Human Mesenchymal Stem Cells
Matrix elasticity can regulate stem cell self-renewal and can direct differentiation. This image shows the effect of spatial organization and the magnitude of sub-cellular matrix mechanical properties on human mesenchymal stem cells using hydrogels fabricated with spatially distinct regions. Immunostaining of paxillin in green displays clustered structures, which indicate the formation of mature focal adhesions on the stiff regions of the hydrogel. The nucleus is depicted in blue and F-actin in red.
This photo was chosen as a winner of the 2016 NIH funded research image call.
Credit: Chun Yang, Hao Ma and Anouk Killaars, University of Colorado Boulder
NIH funding from: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)