This was me on Saturday after a series of errors (some on my part) led to me losing BOTH hard drives in my "redundant" back up.
Yes, you read that right. Some 44,000 photos gone in the matter of minutes.
I have some secondary backups of certain things but that's less than 20%. I'm not too concerned with any of the stuff that was uploaded to flickr, most of that stuff is replaceable over time.
Its the loss of all the wedding, social, family and party photos that is most troubling.
Let this be a warning everyone, back up frequently and to more than once place.