Downtown Buffalo, New York
Buffalo is the second most populous city in the state of New York, after New York City. Located in Western New York on the eastern shores of Lake Erie and at the head of the Niagara River across from Fort Erie, Ontario, Buffalo is the seat of Erie County and the principal city of the Buffalo-Niagara Falls metropolitan area, the largest in Upstate New York. Buffalo itself has a population of 261,310 (2010 Census) and the Buffalo–Niagara–Cattaraugus Combined Statistical Area is home to 1,215,826 residents.
Today, the region's largest economic sectors are health care and education, and these continue to grow despite the lagging national and worldwide economies.