Cute Clones

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    Different ages, but cloned in Korea from the same deceased mother.

    They have no father, but three mothers contributed to their birth: Missy for DNA, another for an embryo (and mitochondrial DNA), and a third surrogate mom for implantation and fetal development.

    Because of their random estrous cycles, dogs are among the most difficult animals to clone.

    MissyToo was full of beans. I first saw her “sister” with Lou in a canoe on Echo Lake.

    They dropped by for lunch today, just as a "news" item broke of three human clones living in Eastern Europe.

    Coco Mault, Marcelo Savoini, and 11 other people added this photo to their favorites.

    View 10 more comments

    1. biotron 63 months ago | reply

      ditto Todd... well said :)

    2. jmcminn 63 months ago | reply

      Cloning = bad idea

    3. Carleton! 63 months ago | reply

      That logic could also apply to Aspertame.

    4. The Rocketeer 63 months ago | reply

      I don't get your point, Carleton... it could also apply to a lot of things... so?

    5. Carleton! 63 months ago | reply

      I guess my point is that all things are natural if you consider that it's natural to make stuff in a lab.

      I don't want to argue. Was just trying to make a dorky joke. I'm not a religious zealot in any sense of the word.

      I believe that science for science's sake is awesome (I'm an engineer). But, as we all know, there are those that will undoubtedly look to apply such technology for more purposes than originally intended. Look where gunpowder got us.

    6. AMagill 63 months ago | reply

      I would have expected more difference in their coats, as a result of slight environmental variations affecting the fur color morphogenesis during development. I'd be curious to see the result of cloning an animal where morphogenesis plays a stronger role, such as creating spots or stripes.
      I wonder what other dogs think of meeting two dogs with nearly identical scents?
      Very cute dogs. :)
      jmcminn: That's a heck of a blanket statement. Do you suppose you'll still be saying that if/when in the near future you're offered a cloned replacement organ to save your life? Of course, as with any science and technology, there are great and subtle evils to be avoided. Few things, though, bother me more than statements of '[field of study] = [evil/bad/unnatural/etc.]'.

    7. The Rocketeer 63 months ago | reply

      Thanks for the clarification, Carleton!

      Steve's photos have all the interesting comments...

    8. ~Reshma~ 63 months ago | reply

      Ha! I knew from the thumbnail that a photo of 2 dogs wasn't just about dogs.

      Cloning humans - it is inevitable, isn't it? But imagine if someone like the Octuplets' mom takes a fancy for cloning... *shudder*

      On a funnier note, Calvin and Hobbes comes to mind - when Calvin's 'Duplicator' clones 6 Calvins. What a riot! :-)

    9. NYCArthur 63 months ago | reply

      pretty amazinzg - thanks for this.

      Octoslam at Denny's - a plate of 8 over easy eggs, NO Sausage, and the guy sitting next to you Pays for it.

    10. j_silla 63 months ago | reply

      I won't be surprised, if they suddenly started thinking and talking like humans. :)
      Good news, as longas they are not hurt when created. Interesting how many times they had to try before succeeding? Few years ago the falure rate was really high.

    11. jurvetson 63 months ago | reply

      Vanita - righteous!

      Jane - 12 and 15 months.

      Rocketeer - Not sure, but we have all kinds of interesting nature/nurture experiments to consider. I would guess that coat variation has some developmental randomness, like human fingerprints, which are different for identical twins. Also, with these dogs, the coat pattern changes a bit with age.

      AMagill - They are considering novel colors, extended lifespan, double muscle, and other features.

      Imagine clone horse racing. All the horses have the same genes. It's like leveling nature for NASCAR where the cars are the same. Nurture and jockey skills become the art...

    12. AMagill 63 months ago | reply

      Jurvetson- Would they increase muscle by deliberately giving the dog a myostatin disorder? (Anybody who doesn't know what that is, you'll be amused by this.) By other colors, do you mean other than white, black, brown or yellow? I also wonder how extended lifespan would work, aside from selecting dogs with exceptionally good health.
      Perhaps they could knock out allergen production?
      How long until we can program genetic memory to produce instinctually well-trained dogs? :)

    13. Shoshin Seishu 63 months ago | reply

      Selection effects are often not the product of monotonic functions, that is, selecting for one characteristic often brings along other, unanticipated variations (mutations).

      Am painfully ambivalent about cloning of both human & non-human animals.

    14. OldUncleMe 62 months ago | reply

      My ambivalence produces no pain at all: cloning isn't really necessary when it comes to pet dogs. I'm not sure that it's the highest and best use of science, but it is an undeniable advancement to scientific knowledge as whole; how does the race of man progress by cloning dogs though? Would population control and improvements in social science not rank ahead of this sort of 'toy' effort in improving the lot for all?

      /.. [TWTME pool.]

    15. Pet Charts 62 months ago | reply

      Congratulations, your photo made the Pet Charts for March 12, 2009! Vote it up the charts at:

      petcharts.purina.com/Default.aspx?day= 2009-3-12

    16. jurvetson 62 months ago | reply

      Purina likes it!

      Vote for M&M!

      AMagill - yes, the "concept cat" will be a nice hypoallergenic purple. Interestingly, people are not willing to pay as much for a cloned cat as a dog. They are cheaper to make, but the market price difference is greater...

    17. OscarFalcon 60 months ago | reply

      If a cloned cell is different in age, does that mean that the first younger cell once gone into growth is better than the older cell? how does science cope with the cell cycles and cloning? is it better to star from a younger cell or are all cells at all ages the same, from the same individual, DNA?

    18. KeizGoesBoom 48 months ago | reply

      they are gorgeous, interesting story too. what breed(s) are they?

    19. jurvetson 48 months ago | reply

      They are near-Missies.

      =) The original Missy was a mixed-breed border collie and Siberian husky.

      Soka: they create a new germ cell, so the age of the cell does not have the same meaning. I think they source germ cells from Missy too, so cell division would not have happened yet. But if not, your question is interesting as telomere snipping would already be underway...

    20. DanVoglesong 46 months ago | reply

      Hi, I'm an admin for a group called ~GMO Free World~sans OGM~Gentechnikfrei~No Quiero Transgenicos~, and we'd love to have this added to the group!

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