A team of researchers has developed a system that uses ultrasound to remotely activate genetic processes inside CAR-T cells so that they can target and kill cancer cells. This work addresses one of the major challenges of of CAR-based immunotherapy: non-specific targeting of CAR-T cells against nonmalignant tissues. Researchers say this work could ultimately lead to more precise and efficient CAR-T cell therapies that can better target malignant over benign tissues.
Press release: jacobsschool.ucsd.edu/news/news_releases/release.sfe?id=2412
Photos by David Baillot/UC San Diego Jacobs School of Engineering