Ambrosio was 12 years old, she enrolled in modeling classes, then began modeling for Dilson Stein at age 15. Her first notable modeling job was the cover of Brazilian Elle magazine.She has since worked with brands including Revlon, Christian Dior, Giorgio Armani, Rolex, Oscar de la Renta, Gucci, Escada, Rocco Barocco, Calvin Klein and Ralph Lauren, as well as the Pirelli Calendar.Ambrosio launched her line of swimwear called Alessandra Ambrosio by Sais, a division of Rosa Chá. It sold 10,000 units in only its first month on the market.
Ambrosio’s best-known collaboration is with American lingerie brand Victoria’s Secret. She appeared in the Victoria’s Secret Fashion Show for the first time in 2000. By 2004, she was selected as the first spokesmodel for the Victoria’s Secret “PINK” line and became a contracted “Angel.” In 2005, she notably walked the Victoria’s Secret Fashion Show runway wearing lingerie made entirely out of candy. Ambrosio then garnered attention in the 2008 edition of the Fashion Show, walking the runway only three months after giving birth to her first child. She opened the show the following year.
Ambrosio was the face for the UK company Next and starred in their first television campaign in 12 years.She is also signed to Storm Model Management in London.