Inspired by a photo of Philip Roth by Olaf Blecker. Seen here, with lighting diagram
Strobist: Much like the diagram; tiny softbox on 430ex high and camera right, shoot-through umbrella with 580exII high and camera left. Both about 6.5-7' away, with similar power.
A little Photoshop to desaturate and enhance detail. Speedlights just don't have the watts to shoot f22 like Olaf.
Flickr is doing a terrible thing to the shirt texture on resize, see the original size.