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PLGA Microsphere

PLGA (poly lactic-co-glycolic acid) is a biodegradable and biocompatible copolymer that is widely used in the pharmaceutical industry as a drug delivery vehicle.PLGA microspheres were attached to a SEM stub with a carbon adhesive disc and being transferred using a squirrel hair brush. Excess sample was removed with a gentle spray of compressed air and then placed into the FEI Quanta FEG 200 for imaging. To enhance surface morphology of the spheres, a low accelerating voltage of 2KV was selected to be the optimum for this kind of sample with a chamber pressure of 180 Pascal’s. A digital image was captured, imported into photoshop and coloured by Steve Gschmeissner.


Courtesy of David McCarthy


Image Details

Instrument used: Quanta Family

Magnification: 1000x

Horizontal Field Width: 298um

Vacuum: 180Pa

Voltage: 2.00KV

Spot: 3.0

Working Distance: 4.3mm

Detector: LFD


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Taken on March 9, 2010