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Small Cell Carcinoma, Pleural Fluid Cytology

63-year-old woman with smoking history presented with opacification of one lung lobe, markedly enlarged thoracic lymph nodes, and radiographic evidence of pleural and systemic metastases.


Pap stain of Cytospin preparations showed several groups like the one pictured here: small dark cells with prominent nuclear molding, finely granular chromatin, inconspicuous nucleoli, scanty cytoplasm, and indistinct cell margins.


Original magnification: 1000X, oil immersion.

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Taken on February 23, 2007