Dey Brothers Department Store was founded in 1877. It was the high-end department store in Syracuse. This building was designed by Archimedes Russell in 1893. It merged with its competitor the Addis Company in the late 1980s. It then merged with another small department store chain out of Connecticut, Sage-Allen. This store closed in 1992, and the entire chain shut down in 1994.
Supposedly the Dey Brothers Department Store is on the National Register, but I cannot find the National Register number.