Pulsatilla vulgaris, syn. Anemone pulsatilla, blooming at Distant Hill Gardens in Walpole New Hampshire. Pulsatillas, or Pasque Flowers are highly toxic. The anemonin compound in Pulsatilla is a powerful irritant, and overdoses cause violent gastroenteritis, vomiting, looseness of the bowels, convulsions and even coma. Even so, some Native Americans have used Anemone pulsatilla as a medicine for centuries.