My sister's family and I wanted to play Wii together, but they are 2,700 miles away.
I set up an iPhone 4S FaceTime call, with the phone held static by a mic stand. Used a Jambox for the audio. Actually worked well. You can put the phone off to the side too, of course. (The Jambox acts as a speakerphone, so you don't have to be near the phone to speak and listen.)
Game flow was good, but can only play turn-based games like Bowling and Golf of course.