The Macau Grand Prix was originally conceived in 1954 as a treasure hunt around the streets of the city, but shortly after it was suggested that the hunt's track could host an amateur racing event for local motor enthusiasts. The race continued as an amateur race until 1966, when Belgian driver Mauro Bianchi entered the race with a car by Renault Sport, mostly to promote Renault's image in Hong Kong. This led to more and more professional teams entering the Grand Prix.
The motorcycle race was introduced in 1967, and in that year the first fatal tragedy struck the race: double champion Dodjie Laurel
(1st back to back champion 1962~ 1963) was killed when he lost control of his car and crashed. This raised the alarm for more safety improvements for the race.
source: Wiki