TheJCB's photostream

Zylbersztejn et al. reveal that the vesicular SNARE protein Synaptobrevin 2 is required for Semaphorin 3A–dependent axonal repulsion. Axons expressing the Semaphorin 3A co-receptor Neuropilin 1 (red) are arranged normally in a control mouse brain (left) but are disorganized in the absence of Synaptobrevin 2 (right).

Image © 2012 Zylbersztejn et al.

Reference Zylbersztejn et al. (2011) J. Cell Biol. 196, 37-46.
Published on: January 9, 2012.
doi: 10.1083/jcb.201106113

Read the full article online at: jcb.rupress.org/content/196/1/37.full

Wynne et al. visualize meiotic chromosome dynamics in live C. elegans animals. A time-lapse series (top) shows that movements of the X chromosomes (magenta) are mostly led by the pairing centers (green)—specialized chromosome regions that drive homologue pairing in early meiosis. Mapping the trajectories of multiple pairing centers on a
representative nucleus (bottom) illustrates how their motions cover the nuclear envelope to help chromosomes find their homologous partner.

Image courtesy of David Wynne and Ofer Rog.

Reference Wynne et al. (2011) J. Cell Biol. 196, 47-64.
Published on: January 9, 2012.
doi: 10.1083/jcb.201106022

Read the full article online at: jcb.rupress.org/content/196/1/47.full

Baez et al. identify S-foci, neuronal cytoplasmic granules containing the translational repressor Smaug1 (red), which control synapse formation by regulating the local translation of mRNAs encoding the kinase CaMKIIalpha (green) and other proteins after NMDA receptor
stimulation.

Image © 2011 Baez et al.

Reference Baez et al. (2011) J. Cell Biol. 195, 1141-1157.
Published on: December 26, 2011.
doi: 10.1083/jcb.201108159.

Read the full article online at: jcb.rupress.org/content/195/7/1141.full

A 3D-rendered time-lapse series shows the disassembly of the mitotic spindle (orange) after inactivation of the cyclindependent kinase Cdk1. Hégarat et al. reveal that spindle microtubules are stabilized in the absence of Aurora A and Aurora B activity, indicating that these two mitotic kinases regulate anaphase microtubule dynamics.

Image courtesy of Nadia Hégarat and Helfrid Hochegger.

Reference Hégarat et al. (2011) J. Cell Biol. 195, 1103-1113.
Published on: December 26, 2011.
doi: 10.1083/jcb.201105058.

Read the full article online at: jcb.rupress.org/content/195/7/1103.full

Daskalaki et al. reveal that ubiquitylation of the intracellular domain of the Notch ligand Delta is required for Notch activation. Ectopic expression of wild-type Delta (green, left) in Drosophila larval wing epithelia induces a stripe (white arrow) of wg (red), a Notch target gene. But a Delta mutant (green, right) unable to bind the E3 ubiquitin
ligase Mindbomb1 fails to induce wg expression.

Image © 2011 Daskalaki et al.

Reference Daskalaki et al. (2011) J. Cell Biol. 195, 1017-1031.
Published on: December 12, 2011.
doi: 10.1083/jcb.201105166

Read the full article online at: jcb.rupress.org/content/195/6/1017.full