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IGFR complexed with allosteric inhibitor | by Enzymlogic
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IGFR complexed with allosteric inhibitor

The Insulin-like Growth Factor 1 (IGF-1) Receptor is found on the surface of human cells and is activated by two different hormones, IGF-1 and IGF-2. IGF1R is frequently overexpressed in tumors, including melanomas, cancers of the colon, pancreas, prostate and kidney. In cancer cells, IGFR-1 contributes to the promotion of tumor growth by inhibition of the apoptosis, transformation and induction of angiogenesis. Feel free to use this image, just link to www.enzymlogic.com. Work done with the molecular visualization VMD program developed at the University of Illinois: www.ks.uiuc.edu/Research/vmd/

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Uploaded on September 13, 2013